Table 3. Schistosoma prevalence and geometric mean egg count by study week and randomisation and comparison groups.
| Time point | Prevalence
geometric mean) |
High-intensity
PZQ (n=113) |
Low-intensity PZQ
(n=113) |
p-value ^ | Comparison n=137 | p-value $ |
|---|---|---|---|---|---|---|
| 12 weeks | ||||||
| Kato Katz microscopy | Prevalence | 23/105 (21.9%) | 79/109 (72.5%) | <0.01 | 9/124 (7.3%) | <0.01 |
|
*Geometric mean egg
count (95%CI) |
115.7 (73.9-181.1) | 288.4 (215.8-385.6) | <0.01 | 82.3 (32.8-206.4) | 0.43 | |
| CAA | prevalence | 66/97 (68.0%) | 86/97 (88.7%) | <0.01 | 13/82 (15.9%) | <0.01 |
|
*Geometric mean pg
CAA / mL (95% CI) |
369.1 (247.2-551.2) | 2041.5 (1395.5-2986.7) | <0.01 | 219.5 (100.6-478.8) | 0.44 | |
| 36 weeks | ||||||
| Kato Katz microscopy | Prevalence | 9/98 (9.2%) | 22/99 (22.2%) | 0.01 | 11/119 (9.2%) | 0.99 |
|
*Geometric mean egg
count (95%CI) |
61.3 (33.1-113.6) | 136.1 (90.2-205.3) | 0.05 | 38.7 (27.6-54.3) | 0.17 | |
| 60 weeks | ||||||
| Kato Katz microscopy | Prevalence | 6/91 (6.6%) | 31/96 (32.3%) | <0.01 | 8/107 (7.5%) | 0.81 |
|
*Geometric mean egg
count (95%CI) |
54.6 (22.4-133.0) | 191.5 (124.5-294.7) | 0.01 | 59.1 (36.4-95.9) | 0.55 | |
| CAA | prevalence | 26/89 (29.2%) | 69/94 (73.4%) | <0.01 | 14/103 (13.6%) | 0.01 |
|
*Geometric mean pg
CAA / mL (95%CI) |
295.5 (152.0-
574.4) |
695.1 (463.8-1041.6) | 0.03 | 103.3 (62.8-169.9) | 0.04 | |
| Other helminths | ||||||
| 12 weeks | Prevalence | 6/106 (5.7%) | 13/109 (11.9%) | 0.11 | 9/124 (7.3%) | 0.63 |
| 36 weeks | Prevalence | 7/98 (7.1%) | 7/99 (7.1%) | 1.00 | 5/119 (4.2%) | 0.37 |
| 60 weeks | Prevalence | 1/91 (1%) | 1/96 (1%) | 0.99 | 0/109 (0.0%) | 0.60 |
PZQ praziquantel. * Geometric mean among those infected, ^High-intensity PZQ to Low-intensity PZQ group, $ High-intensity PZQ vs comparison, CAA-serum circulating anodic antigen