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. 2018 Aug 2;52(23):1497. doi: 10.1136/bjsports-2018-099308

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© Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Transmission electron microscopy reveals the close cell–ECM interaction in human skeletal muscle (musculus vastus lateralis, 25 000× magnification) allowing a bidirectional cell–ECM interaction. Myofilaments (MF) are connected by Z-lines (Z) and costameres (C) to the adjacent basal lamina (BL) and the surrounding reticular lamina (RL). Crossbridging structures (arrows) connect the Z-lines and costameres to the dense part of the basal lamina. The reticular lamina is structured by a network of collagen fibrils (CF) and additional ECM molecules, which have a close connection to the basal lamina allowing bidirectional transmission of mechanical forces. ECM, extracellular matrix.