Study schema for GOG 0277, a randomized phase III trial of chemotherapy versus observation in uterus-limited, high-grade uterine LMS. BSO, bilateral salpingo-oophorectomy; CT, computed tomography; FIGO, International Federation of Gynecology and Obstetrics; GCSF, granulocyte-colony stimulating factor; IV, intravenous; LMS, leiomyosarcoma; MRI, magnetic resonance imaging.