Table 3.
Allele and genotype distribution of TLR2 SNPs in the Riyadh region compared to other populations
| Population | Genotype frequency (N) | Allele frequency | χ2 | P-value | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| rs3804099 | TT | CT | CC | T | C | |||
| CRS (102) | 0.275 (28) | 0.461 (47) | 0.265 (27) | 0.505 | 0.495 | 0 | 0 | |
| CEU (224) | 0.268 (60) | 0.562 (126) | 0.170 (38) | 0.549 | 0.451 | 0.5479 | 0.4592 | |
| HCB (86) | 0.302 (26) | 0.651 (56) | 0.047 (4) | 0.628 | 0.372 | 2.8712 | 0.0902 | |
| JPT (172) | 0.535 (92) | 0.395 (68) | 0.070 (12) | 0.733 | 0.267 | 14.6067 | <0.005** | |
| YRI (226) | 0.159 (36) | 0.425 (96) | 0.416 (94) | 0.372 | 0.628 | 5.1193 | 0.0237* | |
| MEX (100) | 0.400 (40) | 0.500 (50) | 0.100 (10) | 0.65 | 0.35 | 4.3549 | 0.0369* | |
| MKK (286) | 0.112 (32) | 0.503 (144) | 0.385 (110) | 0.364 | 0.636 | 6.2142 | 0.0127* | |
| TSI (176) | 0.330 (58) | 0.477 (84) | 0.193 (34) | 0.568 | 0.432 | 1.0367 | 0.3086 | |
|
| ||||||||
| rs3804100 | TT | CT | CC | T | C | |||
| CRS (103) | 0.019 (2) | 0.184 (19) | 0.796 (82) | 0.888 | 0.112 | 0 | 0 | |
| CEU (226) | 0.850 (192) | 0.150 (34) | 0 | 0.925 | 0.075 | 1.2031 | 0.2727 | |
| HCB (86) | 0.372 (32) | 0.581 (50) | 0.047 (4) | 0.663 | 0.337 | 14.1407 | <0.005** | |
| JPT (166) | 0.578 (96) | 0.410 (68) | 0.012 (2) | 0.783 | 0.217 | 4.8500 | 0.0276* | |
| YRI (226) | 0.876 (198) | 0.124 (28) | 0 | 0.938 | 0.062 | 2.4384 | 0.1184 | |
| MEX (100) | 0.820 (82) | 0.180 (18) | 0 | 0.910 | 0.090 | 0.2620 | 0.6088 | |
| MKK (286) | 0.951 (272) | 0.049 (14) | 0 | 0.976 | 0.024 | 12.9344 | <0.005** | |
| TSI (176) | 0.875 (154) | 0.125 (22) | 0 | 0.938 | 0.062 | 2.1681 | 0.1409 | |
|
| ||||||||
| rs4696480 | AA | AT | TT | T | A | |||
| CRS (92) | 0.272 (25) | 0.446 (41) | 0.283 (26) | 0.505 | 0.495 | 0 | 0 | |
| CEU (110) | 0 | 0 | 1.000 (110) | 1.000 | 0 | 70.2188 | <0.005** | |
| HCB (88) | 0 | 0 | 1.000 (88) | 1.000 | 0 | 58.2447 | <0.005** | |
| JPT (82) | 0 | 0 | 1.000 (82) | 1.000 | 0 | 54.9141 | <0.005** | |
| YRI (120) | 0 | 0 | 1.000 (120) | 1.000 | 0 | 75.5660 | <0.005** | |
Notes: Data were obtained from The International HapMap Project39 (NCBI retired the HapMap resource on June 16, 2016).
*
P<0.05 and
**
P<0.005. Values in bold are significant.
Abbreviations: CEU, Utah residents with northern and western European ancestry from the CEPH collection; CEPH, Centre d’Etude du Polymorphisme Humain; CRS, central region population of Saudi Arabia; HCB, Han Chinese in Beijing, People’s Republic of China; JPT, Japanese in Tokyo, Japan; MEX, Mexican ancestry in Los Angeles, California; MKK, Maasai in Kinyawa, Kenya; TLR, Toll-like receptor; TSI, Toscani in Italia; YRI, Yoruba in Ibadan, Nigeria.