Table 5.

Genotype frequencies of TLR2 gene polymorphism in colorectal cancer male/female vs control

SNP ID	Genotype	Colon, n (frequency)	Controls, n (frequency)	OR	95% CI	χ2 value	P-value*
Male vs control
rs3804099	CC	10 (0.16)	13 (0.22)	Ref
	CT	31 (0.50)	26 (0.45)	1.55	0.58–4.11	0.78	0.38
	TT	21 (0.34)	19 (0.33)	1.43	0.51–4.03	0.48	0.49
	CT + TT	52 (0.84)	45 (0.78)	1.50	0.60–3.75	0.76	0.38
	C	51 (0.41)	52 (0.45)	Ref
	T	73 (0.59)	64 (0.55)	1.16	0.70–1.94	0.33	0.56
rs3804100	CC	1 (0.02)	2 (0.04)	Ref
	CT	8 (0.12)	9 (0.15)	1.78	0.13–23.52	0.19	0.66
	TT	56 (0.86)	48 (0.81)	2.33	0.20–26.54	0.49	0.48
	CT + TT	64 (0.98)	57 (0.86)	2.25	0.20–25.43	0.45	0.50
	C	10 (0.08)	13 (0.11)	Ref
	T	120 (0.92)	105 (0.89)	1.49	0.63–3.53	0.81	0.37
rs4696480	AA	19 (0.32)	14 (0.27)	Ref
	AT	25 (0.42)	23 (0.44)	0.80	0.33–1.96	0.24	0.63
	TT	15 (0.26)	15 (0.29)	0.74	0.27–1.99	0.36	0.55
	AT + TT	40 (0.68)	38 (0.73)	0.78	0.34–1.76	0.37	0.54
	A	63 (0.53)	51 (0.49)	Ref
	T	55 (0.47)	53 (0.51)	0.84	0.50–1.42	0.42	0.52
Female vs control
rs3804099	CC	9 (0.18)	13 (0.31)	Ref	0.46–3.748	0.25	0.62
	CT	19 (0.39)	21 (0.50)	1.31	1.17–12.30	5.13	0.023*
	TT	21 (0.43)	8 (0.19)	3.79	0.75–5.28	1.95	0.16
	CT + TT	40 (0.82)	29 (0.69)	1.99	1.163.79	6.03	0.014*
	C	37 (0.38)	47 (0.56)	Ref
	T	61 (0.62)	37 (0.44)	2.09
rs3804100	CC	1 (0.02)	0 (0)	Ref	0.007–5.60	1.61	0.20
	CT	5 (0.10)	9 (0.21)	0.19	0.02–10.97	0.76	0.38
	TT	43 (0.88)	33 (0.79)	0.43	0.02–9.59	0.87	0.35
	CT + TT	48 (0.98)	42 (1)	0.38	0.56–4.39	0.72	0.40
	C	7 (0.08)	9 (0.11)	Ref
	T	91 (0.92)	75 (0.89)	1.56
rs4696480	AA	8 (0.17)	10 (0.26)	Ref
	AT	24 (0.51)	18 (0.48)	1.67	0.55–5.07	0.82	0.37
	TT	15 (0.32)	10 (0.26)	1.88	0.55–6.39	1.02	0.317
	AT + TT	39 (0.83)	28 (0.74)	1.74	0.61–4.97	1.09	0.30
	A	40 (0.43)	38 (0.50)	Ref
	T	54 (0.57)	38 (0.50)	1.35	0.74–2.48	0.94	0.33

Note:

^*P<0.05.

Abbreviations: Ref, reference; SNP, single-nucleotide polymorphism.