Table S3.
Top 20 topological network nodes in first-layer’s PPi
| Degree | Name | GO annotation |
|---|---|---|
|
| ||
| 86 | PIK3CA | Protein serine/threonine kinase activity and signaling pathway |
| 74 | TP53 | Transcription factor activity |
| 72 | MAPK1 | Protein serine/threonine kinase activity and signaling pathway |
| 68 | HSPA8 | Chaperone and protein folding |
| 64 | ACACA | Acetyl-CoA carboxylase activity |
| 63 | CAD | Aspartate carbamoyltransferase activity |
| 62 | ACACB | Acetyl-CoA carboxylase activity |
| 61 | POTEF | Retina homeostasis |
| 60 | LRRK2 | Protein serine/threonine kinase activity |
| 58 | IL8 | Neutrophil chemotaxis |
| 54 | POTEE | Retina homeostasis |
| 53 | POTEI | Retina homeostasis |
| 53 | POTEJ | Retina homeostasis |
| 53 | PHLPP1 | Protein dephosphorylation and signaling pathway |
| 53 | RIPK4 | Protein serine/threonine kinase activity |
| 53 | PHLPP2 | Protein dephosphorylation |
| 52 | GART | Purine nucleobase biosynthetic process |
| 50 | MYC | Transcription factor activity |
| 48 | GMPS | Purine nucleobase biosynthetic process |
| 47 | OAS2 | Purine nucleobase biosynthetic process |
Abbreviations: GO, Gene Oncology; PPi, protein–protein interaction.