Table 2.

Forty-five DEGs were identified between severe and mild emphysema groups

Functional category	Gene symbol	Dysregulation	P-value	Fold change
Transcriptional regulation	KANK1 PHF1 PHF6 TADA2A TRIM34 ZFHX3 ZNF322 ZNF451	Down Down Up Up Up Down Up Up	5.58E–05 4.45E–05 2.08E–05 8.32E–05 3.85E–06 4.31E–05 2.88E–06 8.66E–05	−1.82 −1.63 2.01 2.42 1.54 −1.54 1.58 2.54
Membrane receptor and signal pathway	BAG4 BCR FYB1 GNB4 GPR65 NPSR1 NPHP4 P2RY13 RNF213 ZFP106 ZC3HAV1	Up Down Up Up Up Down Down Up Up Down Down	0.000061 6.05E–05 5.24E–06 7.66E–05 7.58E–05 7.72E–05 8.48E–05 3.03E–05 6.32E–05 2.71E–05 8.41E–05	1.71 −1.59 2.43 2.49 2.54 −1.73 −1.93 4.2 2 −1.5 −1.43
Metabolism	DPM3 ELOVL3 ETNK2 IMPDH2	Down Down Down Down	7.09E–05 4.72E–05 2.63E–05 7.49E–05	−1.44 −1.47 −1.74 −1.5
Cilium	IFT140 TMEM80	Down Down	1.65E–05 5.48E–05	−1.93 −1.75
Protein modification	USP33 NUP58 PARP16	Up Up Down	2.29E–05 3.89E–05 6.93E–05	2.64 2.96 −1.73
Others	DNAJB14 ZBTB8OS EHBP1 ATP1B2 FAM149A TLN1 SF3A1 FAM168B CYB5D2 KCNJ4 ZCCHC3 MRPS24 swi5 SERPINI1 SVEP1 VPS28 OGFOD3	Up Up Down Down Down Down Down Down Down Down Down Down Down Down Down Down Down	4.21E–05 6.47E–05 9.96E–07 7.85E–06 7.86E–06 2.68E–05 2.46E–05 4.84E–05 3.72E–05 8.54E–05 7.39E–05 4.46E–05 3.21E–05 7.31E–05 5.94E–05 6.99E–05 7.25E–05	2.16 1.65 −1.42 −3.09 −3.32 −1.47 −1.49 −1.71 −1.33 −1.77 −1.57 −1.36 −1.34 −1.58 −1.67 −1.52 −1.57

Note: DEGs were roughly classified according to the BP and MF terms of Gene Oncology by using the Functional Annotation tool in the DAVID database.

Abbreviations: BP, biological process; DAVID, the Database for Annotation, Visualization and Integrated Discovery; DEGs, differentially expressed genes; MF, molecular function.