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. 2018 Nov 14;12:3913–3927. doi: 10.2147/DDDT.S180976

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© 2018 Tan et al. This work is published and licensed by Dove Medical Press Limited

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AS and JQ1 synergistically induced cytochrome c release from mitochondrial to the cytoplasm in gastric and colon cancer cells.

Notes: (A–D) AGS, MGC803, HCT116, and SW480 cells treated with AS (1 or 5 µM) or JQ1 (1 or 10 µM) or in combination for 24 hours, and lysates were probed with antibody against cytochrome c, COX IV, and β-actin. (A) AGS, (B) MGC803, (C) HCT116, and (D) SW480 cells. Molecular weight is measured in kDa. Data represent one of the three identical experiments with similar results. ^*P<0.05, ^**P<0.01.

Abbreviations: AS, arsenic sulfide; CON, control; J, JQ1.