Figure 2.

FSH inhibits the NF-κB pathway to control subcutaneous tumors.

Notes: Tumor tissue was untreated or treated with 20 mIU/mL FSH, and HeLa cells treated with 20 mIU/mL FSH were untreated or treated with µg/mL LPS for 8 hours or 60 hours. (A) NF-κB(p65) activity in vivo and in vitro. (B) On the basis of 20 mIU/mL FSH, the number of HeLa cells treated with LPS for 60 hours was determined. (C) The mRNA levels of genes (CCND1 and CCNE1) related to cell cycle in tumor tissue or HeLa cells. (D) The levels of cleaved CASP3 in tumor tissue or HeLa cells. Data are mean ± SEM (n=3). ^**P<0.01.

Abbreviations: FSH, follicle-stimulating hormone; LPS, lipopolysaccharide; CASP3, Caspase 3.