Table 3.
Comparison of the different variables included in the OCC with the impact measured with the basal CAT and future risk assessed as time until the first exacerbation of any nature
| Criteria of clinical impact | Basal clinical impact | Future risk (time until exacerbation) | ||
|---|---|---|---|---|
| Basal CAT | P-value | OR | P-value | |
| • Dyspnea (mMRC) ○Grade 0 ○Grade 1 ○Grade 2 ○Grade 3 ○Grade 4 |
6.1±3.7 9.5±5.9 15.1±6.8 18.7±6.7 20.4±7.3 |
<0.0001 |
– 1.28 (0.50–2.03) 1.01 (0.59–1.70) 1.41 (0.77–2.58) 2.90 (1.42–5.91) |
0.03 |
| • Rescue medication ○≤3 times/week ○>3 times/week, but <2 times/day ○≥2 times/day |
10.6±6.9 13.0±7.1 15.7±8.0 |
<0.0001 |
– 1.82 (1.10–3.03) 1.84 (1.19–2.85) |
<0.0001 |
| • Physical activity (minutes/day) ○>60 ○30–60 ○<30 |
8.4±5.4 11.2±6.9 15.5±7.8 |
<0.0001 |
– 1.34 (0.90–1.98) 1.29 (0.86–1.93) |
NS |
| • Sputum color ○White ○Dark |
12.5±7.0 16.4±8.3 |
0.005 |
– 1.68 (1.07–2.64) |
0.024 |
| • Basal CAT ○0–10 points ○11–20 points ○21–30 points ○>30 points |
5.8±2.8 14.6±2.6 24.6±2.4 32.0±0.8 |
<0.0001 |
– 1.16 (0.82–1.64) 1.47 (0.94–2.28) 2.37 (0.86–6.50) |
NS |
| Criteria of stability | Basal CAT | P-value | OR | P-value |
| • Exacerbations last 3 months ○No ○Yes |
11.0±6.8 13.6±8.8 |
0.011 |
– 1.85 (1.34–2.58) |
<0.0001 |
| • Perception of improvement since last visit ○Better or the same ○Worse |
10.7±7.2 16.6±7.1 |
<0.0001 |
– 1.37 (0.91–1.91) |
NS |
| • CAT change ○≤2 points ○>2 points |
10.7±7.1 16.6±7.2 |
<0.0001 |
– 1.46 (1.04–2.06) |
0.030 |
Abbreviations: CAT, COPD assessment test; OCC, original control criteria; NS, non significant.