Table S4.

Predictive capacity of a composite event (c-statistic) according to the number of criteria needed to define clinical impact

Number of criteria needed to define low impact	Predictive capacity of composite event (c-statistic)
	Adjustment by BODEx			Adjustment by FEV1(%)
	Global	BODEx ≤2	BODEx ≥3	Global	FEV1 ≥50%	FEV1 ≤49%
All criteria are met	0.613	0.599	0.568	0.618	0.581	0.629
Three criteria are met	0.639	0.586	0.628	0.637	0.615	0.632
Two criteria are met	0.628	0.589	0.611	0.628	0.616	0.619
One criterion is met	0.628	0.589	0.611	0.630	0.619	0.619