Table 3.

Univariate and multivariate analyses of small intestinal adenocarcinoma CSS

Characteristics	5-Year CSS (%)	Univariate analysis		Multivariate analysis
		Log-rank χ2 test	P	HR (95% CI)	P
Marital status		55.054	<0.001		<0.001
Unmarried	39.3			Reference
Married	45.7			0.794 (0.736–0.857)
Gender		1.392	0.238
Male	43.3
Female	42.7
Age (years)		63.046	<0.001		<0.001
<68	46.7			Reference
≥68	39.5			1.161 (1.075–1.254)
Race		2.885	0.236
White	44.1
Black	38.6
Othersa	41.8
Insurance		0.861	0.650
Insured/Medicaid	42.6
Uninsured	43.6
Unknown	43.6
Tumor primary site		240.334	<0.001		0.014
Duodenum	35.6			Reference
Jejunum	53.5			0.840 (0.741–0.951)
Ileum	57.0			0.851 (0.740–0.978)
Meckel’s diverticulum	0			2.207 (0.913–5.333)
Overlapping lesion of small intestine	46.5			0.897 (0.624–1.287)
Small intestine, NOS	48.7			0.967 (0.853–1.096)
AJCC seventh TNM stage		689.047	<0.001		<0.001
I	68.3			Reference
II	65.4			1.144 (0.880–1.489)
III	44.5			1.887 (1.475–2.413)
IV	11.1			3.191 (2.540–4.008)
Unknown/NA/blank(s)	42.4			1.995 (1.604–2.482)
Grade		360.890	<0.001		<0.001
Well differentiated	61.9			Reference
Moderately differentiated	51.3			1.194 (1.002–1.423)
Poorly differentiated	38.1			1.749 (1.464–2.090)
Undifferentiated/anaplastic	34.4			2.030 (1.387–2.971)
Unknown	22.0			1.290 (1.072–1.552)
Histology		24.234	<0.001		0.010
Other adenocarcinoma	43.3			Reference
Mucinous adenocarcinoma	48.6			1.070 (0.924–1.240)
Signet ring cell	24.6			1.312 (1.096–1.571)
Surgery		1,546.559	<0.001		<0.001
Yes	57.2			Reference
No	10.9			3.472 (3.138–3.841)
Unknown	44.7			1.321 (0.745–2.341)

Note:

^aIncluding American Indian/AK native and Asian/Pacific Islander (N=448) and unknown race (N=17).

Abbreviations: AJCC, American Joint Committee on Cancer; CSS, cancer-specific survival; NOS, not otherwise specified.