Figure 2.

(A–C) Bar chart showing the radiological outcomes (results) for evaluable dose escalation events (DEEs) for first (figure 2A), second (figure 2B) and subsequent (figure 2C) DEEs, subclassified by reason for DEE (progressive disease (PD), a mixed radiological response (MR) or drug tolerance and a clinical need to dose escalate (T and CN)). (D) Bar chart of disease control rates for first, second and subsequent DEEs, showing all DEEs and those made as a result of disease progression). PR, partial response; SD, stable disease.