Figure 1.

Increased Hepatic PTP Oxidation and Elevated STAT Signaling in NAFL and/or NASH

(A) 8-week-old male C57BL/6 mice were fed a chow diet, an HFD, or a CD-HFD for 20 weeks. Livers from individual mice were processed for immunoblot analysis for total PTP oxidation.

(B) Liver core biopsies from individual obese humans with no steatosis (NAS = 0) or with NAFLD (NAS 2–4) were processed for immunoblot analysis for total PTP oxidation.

(C) Murine liver extracts immunoblotted for STAT-1 Y701 (p-STAT-1), STAT-3 Y705 (p-STAT-3), or STAT-5 Y694 (p-STAT-5) phosphorylation.

(D) Human livers biopsies processed for immunoblotting. Results are representative of at least three independent experiments.

See also Figure S1.