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. 2018 Nov 15;175(5):1289–1306.e20. doi: 10.1016/j.cell.2018.09.053

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

STAT-1 Is Required for Inflammation, T Cell Recruitment, and Fibrosis

(A–C) Ptpn2^fl/fl, Alb-Cre;Ptpn2^fl/fl, and Alb-Cre;Ptpn2^fl/fl;Stat-1^fl/+ mice were fed an HFD for 40 weeks. Liver tissue was processed for (A) immunoblotting, (B) real-time PCR, and (C) histology monitoring for immune cell infiltrates and fibrosis (Picro Sirius Red).

(D) The recruitment of liver T cells, including activated effector-memory T cells, was assessed by flow cytometry. Representative and quantified results (means ± SEM) results are shown for the indicated number of mice.