Fig 10. Receiver Operating Characteristic (ROC) curves for phospho-Rb S249 and p39, and the table showing the associated numerical values for area under the curve, confidence interval, p-value, sensitivity, and specificity.

The area under the curve is a range between 0.5 (no predictive power) and 1.0 (perfect predictive accuracy). The phospho-Rb S249 score had an area under the curve of 0.7396, while the p39 score had an area of 0.9375, both being close to 1.0 and thus indicating a strong predictive value for grading and staging and metastasis, respectively. Phospho-Rb S249 and p39 scores had a sensitivity of 75% and 87.5%, respectively, meaning that 75% of tumors with high phospho-Rb S249 score also had high grading, and 87.5% of tumors with high p39 score also had high staging and lymph node and distant metastasis. Regarding specificity, the numbers for the phospho-Rb S249 and the p39 scores were 67.65% and 100%, respectively, meaning that 67.65% of the tumors with low scores for phospho-Rb S249 score were also of low grade, while none of the tumors negative for p39 were of a higher stage or had metastasis to lymph nodes or distant sites.