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. 2018 Nov 19;8:16985. doi: 10.1038/s41598-018-35069-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synergistic effect of 5FU and Silibinin on activation of PI3K/MAPK dual pathway in CD44 subpopulation. The effect of silencing and combinatorial drug treatment induced CD44v6 suppression was examined on PI3K/MAPK dual pathway activation of HCT116 derived CD44+ cells. (a) PI3K/MAPK dual activation analysis was conducted on CD44v6 siRNA (10 nM) and 5FU+ Silibinin (10 + 50 μM) treated cells as compared to their untreated counterparts using the Muse^TM analyser based flow cytometry. (b) The graph indicating the percentage of cells in treated cells compared to untreated cell population. Error bars represent mean ± SEM of three independent experiments with p-value indicated as *p < 0.05, **p < 0.01 and ***p < 0.001.