Table 1.
Composition of the Stem Cell Chemical Library used for screening lung adenocarcinoma TPCs
| Compound | Mechanism | Compound | Mechanism |
|---|---|---|---|
| CCPA | A1+ | Compound W | Notch |
| SQ22536 | Acase− | DAPT | Notch |
| Forskolin | Acase+ | DLPC | nr2a5 |
| SR1 | ahr− | 2-Phospho-l-ascorbic acid | P |
| ITE | AHR+ | IPA-3 | Pak− |
| ABT 702 dihydrochloride | AK− | EB-47 | parp1− |
| KP372-1 | AKT− | DMPQ dihydrochloride | pdgf r inh |
| (+)-JQ1- 1 mg | BET− | SU6656 | pdgf/fgf/vegf r inh |
| Dorsomorphin | bmpr− | Mycophenolate mofetil | PDH2 |
| CITCO | CAR | PS48 | PDK1 |
| Indomethacin | cox | 16,16-Dimethyl prostaglandin E2 | PGE2 |
| AMD3100 | cxcr4− | GDC-0941 | pi3k |
| FCCP | decoupl | PI-103 | pi3k− mtor− dnapk− |
| A77 1726 | dhodh | cAMPS-Rp | PKA− |
| RG 108 | DNMT | GSK 0660 | PPARd− |
| 5-Aza-2′-deoxycytidine | DNMT− | BADGE | pparg− |
| 5-Azacytidine | DNMT1− | GW9662 | PPARg− |
| SGC 0946 | DOT1L− | Troglitazone | pparg+ |
| AG 1478 | EGFR | AM 114 | Proteasome |
| Erlotinib | egfr− | NSC 23766 | RAC |
| GSK126 | EZH2− | BMS 493 | RAR+ |
| PF 573228 | FAK | BMS195614 | RARa− |
| PD161570 | fgfr− | AM580 | RARa+ |
| UNC 0638 | g9a inh | AC 261066 | RARb+ |
| Dexamethasone | gc | CD2665 | RARbg− |
| Depudecin | HDAC− | BMS 961 | RARg+ |
| Sodium butyrate | HDAC− | y27632 | rock− |
| Trichostatin A | HDAC− | Blebbistatin | rock/mlck |
| Valproic acid | HDAC− | BI-D1870 | RSK |
| GANT 61 | HH− | W146 | s1p1− |
| Purmorphamine | HH+ | SEW2871 | s1p1+ |
| 20(S)-Hydroxycholesterol | HH+ | Splitomycin | sirp2− |
| IOX2 | HIF+ | ex527 | sirt1− |
| IKK16 | IKK | agk2 | sirt2− |
| Revstarol | jak 3/2/1 inh | A83-01 | tgfb− |
| cp690550 | jak− | repsox | tgfb− alk5− |
| Tranylcypromine HCl | LSD1− | IDE-1 | TGFb+ |
| PD98059 | MAPK | SB431542 | tgfb1 |
| Nutlin | mdm2 inh | TLR3/dsRNA complex inhibitor | tlr3 inh |
| PD0325901 | MEK | MLS000389544 | TR− |
| Rapamycin | mtor | 1–850 | TR+ |
| Honokiol | nfkb− | 3,3′,5-Triiodo-l-thyronine sodium salt | TR+ |
| Betulinic acid | nfkb+ | RN 1734 | TRP channels |
| SNAP | NO | ZM 306416 hydrochloride | vegf r inh |
| DETA NONOate | NO+ | IWP-2 | wnt− |
| l-NAME | NOS− | XAV 939 | Wnt− |
| CHIR99021 | wnt+gsk− |