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. 2018 Nov 19;8:17027. doi: 10.1038/s41598-018-35391-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The examination of mitochondrial pathology using TEM analysis in tenocytes grown under (A) normoxic and (B) hypoxic conditions. Trans-mitochondrial cristae co-ordination (yellow star), mitochondrial compartmentalization (red star) and extension of outer mitochondrial membrane (blue star) were completely absent in normoxic cells when compared with hypoxic cells (B) and the normoxic (A) mitochondria exhibited higher electron density. (C) The figure shows non-significant increase in the mitochondrial aspect ratio in hypoxic mitochondria (n = 27) than that of normoxic ones (n = 10) (NS – non-significant).