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. 2018 Nov 19;8:17037. doi: 10.1038/s41598-018-35071-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Combinatorial 4-MEI supresses glucose anabolism and promotes lipid synthesis. (A) Determination of gluconeogenesis rate during combinatorial treatment via ipPTT, (B) Activity of G6Pase in control and 4-MEI treated animals, (C) Representative immunoblot images of G6Pase and PEPCK in liver tissue during NAS, 4-MEI and combinatorial treatments, (D) Quantification of G6Pase and PEPCK expression. GAPDH served as the loading control for immunoblot. (E) Change in liver glycogen level during NAS, 4-MEI and combinatorial treatments, (F) Altered lipid profile during NAS, 4-MEI and NAS+4-MEI treatment, (G) Representative histopathology photomicrographs of hepatic tissue sections from NAS, 4-MEI and NAS+4-MEI treated animals stained with H & E (400×). * is used to compare experimental groups with the control and # is used for the comparison between NAS and 4-MEI+NAS groups. Error bars represent mean ± sem; ****P < 0.0001, ***P < 0.001, **P < 0.01, P < 0.05/ ^####P < 0.0001, ^###P < 0.001, ^##P < 0.01. Two-way ANOVA with Bonferroni correction and two-sided unpaired Student t-test. Experiments were repeated twice.