Fig. 8.

Effect of 1 and 13 on the compression isotherm of POPE or POPC. a Compression isotherms of a POPE monolayer before (light blue line) and after (dark blue line) incubation with compound 13 (0.2 µM). b Compression isotherms of a POPE monolayer before (light blue line) and after (purple line) incubation with compound 1 (0.2 µM). c Compression isotherms of a POPC monolayer before (yellow line) and after (green line) incubation with compound 1 (0.2 µM). Changes in surface pressure (Δπ) of preformed POPE monolayers at π ~ 25 mN m⁻¹ induced by compound 1 (purple line) or 13 (dark blue) are also shown (inset in a). The compounds were present at the concentration 0.1 µM after the first addition (5 min) and at concentration 0.2 µM after the second addition (90 min). The maximum values of Δπ are 2.61 ± 0.25 mN m⁻¹ for compound 1 and 0.15 ± 0.06 mN m⁻¹ for compound 13 (n = 3)