Table 1.
Compound Nr | MIC (µM) | Cytotoxicity IC50 (µM) | |||||
---|---|---|---|---|---|---|---|
B. anthracis | E. faecalis | B. cereus | 24 h | 48 h | |||
Sterne | Pathogenic | Ovine | |||||
1 | 25 | 25 | 25 | 50 | 25 | 100 | > 50 |
2 | 24 | 48 | 48 | > 48 | 48 | > 50 | > 50 |
3 | 27 | 54 | 54 | > 54 | 27 | > 100 | 100 |
4 | 25 | 25 | 25 | > 50 | 25 | 100 | 50 |
5 | 202 | 101 | 101 | 101 | 202 | n.d. | n.d. |
6 | 24 | 24 | 48 | 48 | n.d. | n.d. | n.d. |
7 | 26 | 52 | 52 | 52 | n.d | > 100 | 100 |
8 | 26 | 26 | 52 | 52 | n.d. | n.d. | n.d. |
9 | 50 | 50 | 50 | 50 | 25 | 100 | 50 |
10 | 27 | 27 | 27 | > 54 | 27 | > 100 | > 100 |
11 | 12.6 | 12.6 | 12.6 | 12.6 | 12.6 | n.d. | 50 |
12 | > 405 | > 405 | > 405 | > 405 | > 405 | n.d. | 50 |
13 | 386 | 12.0 | 12.0 | 12.0 | 386 | 100 | > 50 |
14 | 104 | 51 | 51 | 51 | 51 | n.d. | n.d. |
15 | 51 | 51 | 51 | 51 | 51 | n.d. | n.d. |
16 | 24 | 24 | > 48 | > 48 | 48 | n.d. | n.d. |
17 | 26 | 52 | 52 | > 52 | 52 | > 100 | > 100 |
18 | 26 | 26 | 52 | 52 | 52 | > 100 | > 50 |
19 | 50 | 25 | 50 | 50 | 25 | n.d. | n.d. |
20 | 25 | 50 | 50 | > 50 | 50 | n.d. | n.d. |
21 | 28 | 28 | 28 | 56 | 28 | > 100 | 100 |
Ref.b | 25 | 25 | 25 | 19 | 19 | n.d. | n.d. |
aMüller–Hinton agar dilution method following CLSI guidelines15. bChloramphenicol