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. 2018 Nov 19;8:17036. doi: 10.1038/s41598-018-35379-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pathways analyses – Functional pathways of EV-miRNAs using DIANA Tools miRPath-v3.0. Light blue bars represent pathways enriched among extracellular-packaged miRNAs (EV-miRNAs) detected in all follicular fluid samples, blue bars represent those pathways enriched among EV-miRNAs that were significant in the fertilization status analyses, and the dark blue bars represent pathways enriched among EV-miRNAs that were significant in the day three embryo quality analyses. The red line represents the statistical significant FDR threshold (FDR < 0.05) and the small numbers within each bar are the number of genes found to be associated with those EV-miRNAs.