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fEPSP recordings showing chemically induced LTD in young, but not mature GluA2 KO mice. (A) NMDA (25 μM, 3 min) induces LTD in both young WT and GluA2 KO mice. (B) NMDA (25 μM, 3 min) induces LTD in mature WT but not in mature GluA2 KO mice. (C) DHPG (100 μM, 10 min) induces LTD in both young WT and GluA2 KO mice. (D) DHPG (100 μM, 10 min) induces LTD in mature WT but not in mature GluA2 KO mice.
