Figure 6.

Expression of cofilin and phosphorylated cofilin (p-cofilin) in young and mature GluA2 KO mice. (A,B) Western blots showing that both total baseline cofilin and p-cofilin decrease in mature compared to young mice in both WT and GluA2 KO mice. ***p < 0.001 compared with young mice. (C,D) Western blots showing that baseline cofilin and p-cofilin are similar in WT and GluA2 KO young mice but significantly reduced in mature GluA2 KO mice compared to mature WT mice. **p < 0.01, ***p < 0.001 compared with WT mice, ns: not significant (p > 0.05). (E,F) DHPG activates cofilin in young but not in mature GluA2 KO mice. *p < 0.05, ***p < 0.001 compared with untreated group, ns: not significant (p > 0.05).