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. 2018 Nov 19;8:16983. doi: 10.1038/s41598-018-34952-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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cNETs levels increase after burn and sepsis. (A) Significantly more cNETs are trapped in the microfluidic device after small (comb burn) and large (30% TBSA) burns in rats at 1 PBD (N = 8–13 rats for each group). Data represents the area of trapped cNETs in the devices. Comparisons are performed using the Kruskal-Wallis test; **p ≤ 0.01. (B) Significantly more cNETs are trapped in the microfluidic device from blood of 30% TBSA rats, at 9 PBD and 6 hours after CLP compared to the no CLP (N = 5–8 rats for each group). Data were compared using Mann-Whitney test; *p ≤ 0.05. (C) The area of trapped cNETs in microfluidic devices surges at 1 PBD (N = 8–18 rats for each group). The trapped cNETs area decreases slowly in the days after the injury. The trapped cNETs area increases steadily during sepsis after cecal ligation puncture. Data at each timepoint were compared using Kruskal-Wallis test; *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001.