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. 2018 Nov 19;9(12):1144. doi: 10.1038/s41419-018-1196-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Heatmap of mRNA expression in oocytes showing changes in a subset of genes after Rps26 deletion in Rps26^fl/fl/Zp3-Cre (RZC) and Rps26 ^fl/fl/Gdf9-Cre (RGC) mice compared with the control (CTRL) Rps26^fl/fl mice at PD14 and PD28. b Gene ontology showing the biological processes affected by the altered mRNA expression by comparing the gene expression in the different groups of oocytes at PD14 (2w) and PD28 (4w).c–d Numbers of upregulated (up) genes and downregulated (down) genes in oocytes of control (CTRL) Rps26^fl/fl mice (c) and Rps26 ^fl/fl/Gdf9-Cre mice (d) at PD28 compared to PD14. e–f Numbers of upregulated (up) genes and downregulated (down) genes in oocytes of Rps26 ^fl/fl/Gdf9-Cre mice compared to Rps26^fl/fl mice at PD14 (e) and PD28 (f). g Genes of histone methyltransferases of H3K4 or H3K9 and other related genes were downregulated in Rps26 ^fl/fl/Gdf9-Cre mice compared to Rps26^fl/fl mice as determined from RNA sequencing. *p < 0.05 as calculated by two-tailed Student’s t-tests. Genes involved in DNA methylation and oocyte-specific genes were mostly downregulated in Rps26 ^fl/fl/Gdf9-Cre mice compared to Rps26^fl/fl mice as determined by RNA sequencing. *p < 0.05 as calculated by two-tailed Student’s t-tests