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. 2018 Nov 19;8:16999. doi: 10.1038/s41598-018-35020-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NUPR1 deficiency induces a decrease in the expression of ER stress genes. Total RNA was extracted from MiaPaCa2 cells transfected with siCtrl, siNUPR1-1 or siNUPR1-2 for 72 h to evaluate the mRNA levels of the genes involved in ER stress response using RT-qPCR (A). Western blot analysis was performed to evaluated protein levels of expression of IRE1α, ATF6, PERK and BIP in NUPR1-depleted cells. Data are means of triplicates ± SEM. Statistically significant differences from siCtrl (*p < 0.05, **p < 0.01, ***p < 0.001) was shown.