Table 1.
Nupr1-deficiency induces a downregulation of the ER stress-associated pathways in vitro and in vivo.
| MiaPaCa2 treated with siNUPR1 | |||
|---|---|---|---|
| Pathway ID | Biological process | Downregulated genes | FDR |
| GO:0006986 | Response to unfolded protein | 30 | 7.53e-40 |
| GO:0006457 | Protein folding | 28 | 1.1e-32 |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | 17 | 1.55e-19 |
| GO:0006446 | Regulation of translational initiation | 13 | 2.95e-15 |
| GO:0034976 | Response to endoplasmic reticulum stress | 16 | 9.98e-14 |
| GO:0006984 | Er-nucleus signaling pathway | 8 | 1.48e-10 |
| GO:0036500 | Atf6-mediated unfolded protein response | 6 | 1.48e-10 |
| GO:0036499 | Perk-mediated unfolded protein response | 6 | 1.33e-09 |
| GO:0061077 | Chaperone-mediated protein folding | 8 | 2.17e-09 |
| GO:0006950 | Response to stress | 32 | 5.97e-06 |
| GO:0036498 | Ire1-mediated unfolded protein response | 6 | 2.14e-05 |
| NUPR1 −/− mice | |||
| Pathway ID | Biological process | Downregulated genes | FDR |
| GO:0034976 | Response to endoplasmic reticulum stress | 10 | 7.73e-12 |
| GO:0006986 | Response to unfolded protein | 7 | 6.82e-09 |
| GO:0006457 | Protein folding | 7 | 6.81e-07 |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | 5 | 1.94e-06 |
| GO:0044267 | Cellular response to unfolded protein | 5 | 2.15e-06 |
| GO:0006950 | Response to stress | 12 | 0.00255 |