Fig. 10.

Bulk ATAC-seq analysis of Nkx2-5⁺ CPCs. a Number of differential chromatin accessibility peaks (log2(FC) > 2, false discovery rate [FDR] < 0.05). b Genome-wide distribution of differential open chromatin peaks grouped by K-means. Each row represents one differential peak, normalized to sequencing depth, in sequential comparisons (log2[FC] > 2, FDR < 0.05). c Distribution of genomic features of differential regulatory elements. d Enrichment of known transcription factor motifs in Isl1⁺/Nkx2-5OE differential peaks. The height of the letters represents the frequency of each base in the cognate motif. e Principle component analysis (PCA) showing chromatin accessibility features among indicated samples by reducing dimensionality