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. 2018 Nov 19;9:4877. doi: 10.1038/s41467-018-07307-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Nkx2-5 institutes a unidirectional fate in CPCs to cardiomyocytes. a Re-analysis of published data showing the ratio of smooth muscle cells in embryonic hearts of wild type and Nkx2-5 knockout embryos at E9.5. Smooth muscle cells are scored by low expression of Nkx2-5 (LogTPM < 1, null expression) and high expression of smooth muscle cell genes (Tagln, Cnn1, Acta2, Cald1, Mylk, Hexim1, and Smtnl2 moderate to high (LogTPM > 2) for at least 5 of these 7 genes). χ² test: p < 2.37e−6. n indicates cells numbers. b Schematic illustration of forced expression of Nkx2-5 in Isl1⁺ cells and scRNA-seq. c Predicted diffusion pseudotime of Isl1⁺/Nkx2-5OE cells projected on t-SNE plots of Nkx2-5⁺ and Isl1⁺ d CPCs