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. 2018 Nov 13;9:1214. doi: 10.3389/fphar.2018.01214

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Copyright © 2018 Chen, Zhang, Wang, He, Duan, Zhu, Chen, Yin and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FDTN-loaded NPs regulate the expression of JAK2/STAT3 signaling pathway in H1975 (A) and H1650 (B) cell lines at different concentrations in vitro. (C) ELTN/FDTN co-loaded NPs downregulate p-EGFR and apoptosis-related proteins in H1650 cells in vitro. I: PEG-PLA; II: ELTN@PEG-PLA; III: FDTN@PEG-PLA; IV: ELTN+FDTN@PEG-PLA.