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. 2018 Nov 13;9:1214. doi: 10.3389/fphar.2018.01214

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Copyright © 2018 Chen, Zhang, Wang, He, Duan, Zhu, Chen, Yin and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Immunostaining of p-EGFR and p-STAT3 in tumor sections harvested on day 3 post the last injection of different formulations. Bar represents 100 μm. Quantification of the expression levels of p-EGFR (B) and p-STAT3 (C) from the immuno-stained images (n = 20). I: PBS; II: ELTN@PEG-PLA; III: FDTN@PEG-PLA; IV: ELTN+FDTN@PEG-PLA; V: ELTN+FDTN.