Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 13;9:2542. doi: 10.3389/fimmu.2018.02542

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Platanitis and Decker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Interplay between LDTFs and SRTFs. Pu.1 is an important macrophage lineage–determining factor (LDTF) and a major driving force behind setting up macrophage enhancers for further action by SRTFs. Enhancers are distinguished by high levels of H3K4me1 and are primed by LDTFs, which further displace nucleosomes. Stimulus responsive enhancers and promoters are bound by stimulus-regulated transcription factors (SRTFs), such as STAT, NFκB, and IRF transcription factors, to direct transcriptional responses in the course of inflammation. The binding of SRTFs to primed promoters and enhancers leads to further recruitment of co-activators that deposit the activation mark H3K27ac (5).