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. 2018 Nov 19;8:17010. doi: 10.1038/s41598-018-34718-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Influence of hydrostatic pressure (HP) stimulation on gene expression of transcription factors. Both investigated transcription factors SOX9 and RUNX2 were significantly upregulated in HP-stimulated pellet cultures compared to static pellet cultures on day 21. Although not significantly different, HP-stimulated pellets had higher levels of SOX9 as well as RUNX2 on day 42. Data from 3 individual donors, 5 replicates per donor; **p < 0.01.