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. 2018 Nov 19;9:4883. doi: 10.1038/s41467-018-07329-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Intracellular STM-D23580 reduces CD83 surface expression. a Violin plots showing single-cell gene expression of IL10, JAK2, CLECL1 and CLEC7A at 6 h p.i. in infected and uninfected cells. b Violin plots showing single-cell gene expression of CD83 at 4 and 6 h p.i. in all experimental groups. c Flow cytometry histograms showing the expression of surface CD83 on gated infected and bystander cells challenged with STM-D23580 (blue), STM-LT2 (green) or left uninfected (grey) for 6, 10 or 24 h. STM-D23580-infected MoDCs display decreased surface expression of CD83 as compared with STM-LT2. Histograms from one representative example of at least four biological replicates. d STM-D23580 infection reduces surface CD83 levels detected by flow cytometry. On the y-axis, the geometric mean of fluorescence levels for CD83 on STM-D23580-infected cells is represented as a percentage of the level in STM-LT2-infected cells, set at 100%. Four independent experiments are shown. Two-tailed paired Student’s t-test, P-value < 0.05 (*)