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. 2018 Nov 19;8:17058. doi: 10.1038/s41598-018-35189-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Takinib reduces the cytokine and chemokine response in pro inflammatory stimulated THP-1 human macrophages. THP-1 cells were differentiated in 100 nM PMA for 72 hours followed by a 48-hour rest period, cells were either left unstimulated (resting) or activated with LPS (10 ng/mL) and IFNγ (50 ng/mL) and treated with 10 μM Takinib or DMSO. 110 cytokine and chemokine proteins were profiled. Takinib reduces the expression of 17 different cytokines and chemokines in response to LPS and IFNγ stimulation (a). GROα, IL-6, IL-23, TNF, MCP-3 and Thrombospondin-1 levels in pro-inflammatory treated DMSO (n = 3 ± SEM), 10 μM Takinib (n = 4 ± SEM), or resting cells (n = 4 ± SEM) (b–g). (ANOVA with Dunnett’s) RFU = Relative Fluorescent Units *p < 0.05, **p < 0.01, ***p < 0.001.