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. 2018 Nov 19;9:4866. doi: 10.1038/s41467-018-06699-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — TBX2 is a super-enhancer marked 17q transcription factor in NB. a Prioritization strategy to find SE-driven candidate oncogenes on chr17q. b H3K27ac activity in a region upstream of TBX2 in 26 NB cell lines (blue), non-malignant neural crest cell lines (green) and the non-embryonal breast cancer cell line MCF-7 (green). The Lilly annotated SE regions are indicated in red. The cluster (out of 276 clusters on chr17q) containing the overlapping SE used in the prioritization process is annotated at the bottom. c Kaplan–Meier analysis (overall survival) of 276 neuroblastoma patients (NRC NB tumor cohort, GSE85047) with high or low expression (using median as cut-off) of the five prioritized candidate oncogenes (TBX2, NFE2L1, SP2, RARA, and VEZF1). d TBX2 is highly expressed during embryogenesis as compared to normal adult tissue. TBX2 is highly expressed in NB tumors and NB cell lines as compared to tumors or cell lines from other entities. Boxplots are drawn as a box, containing the 1st quartile up to the 3rd quartile of the data values. The median is represented as a line within the box. Whiskers represent the values of the outer two quartiles maximized at 1.5 times the size of the box. If one or more values outside of the whiskers are present, then this is indicated with a single mark ‘x’ next to the implicated whisker