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. 2018 Nov 13;9:2601. doi: 10.3389/fimmu.2018.02601

Figure 3.

Figure 3

Distribution of unique somatic IL-33 gene mutations in tumors and in the domain regions of the IL-33 protein. (A) IL-33 gene mutations in each tumor have been obtained by inferring the publicly available cBioPortal database for analysis of large-scale cancer genomics data sets (http://www.cbioportal.org/). For each tumor type the number of mutations (n) and the total number of sample patients is depicted. The IL-33 gene mutation positions are aligned to the three principal regions of the IL-33 protein. R1, Chromatin binding domain (M45XLRSGXXI53); R2, Cleavage site for inflammatory Proteases (T90VECFAFGISGVQKYTRALHDSS112); R3, Cleavage site for caspase 3 and caspase 7 (D175GVDG179). Some missense (red text) and truncation (black text) mutations are depicted. (B) Somatic IL-33 gene mutation frequencies calculated by data analyzed in (A) and indicated for each tumor type.