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. 2018 Nov 19;9:4872. doi: 10.1038/s41467-018-07342-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Tentative scheme of pyruvate fermentation metabolism in S. multivorans and S. cavolei. Reactions represented by solid arrows belong to the core pyruvate metabolism and are catalyzed by both organisms. Reactions with dashed arrows are solely catalyzed by S. multivorans, fumarate hydratase and fumarate reductase are also present in S. cavolei. Hyf might pump protons via its membrane-integral subunits (Supplementary Note 1, Supplementary Table 6 and Supplementary Figures 10–13) which could lead to additional ATP production via chemiosmotic coupling. Question marks indicate enzymes not identified. Fermentation products are highlighted in light blue boxes. Protein abundance ratios (pyruvate alone versus pyruvate/fumarate) are indicated by colored squares (S. multivorans) and circles (S. cavolei) at the protein abbreviations. Color code of the ratios is given in the box at the lower right. Hyf Hyf-like hydrogenase (SMUL_2383–2392; SCA02S_RS01920-RS01965), PFOR pyruvate:ferredoxin oxidoreductase (SMUL_2630; SCA02S_RS04525), PTA phosphotransacetylase (SMUL_1483; SCA02S_RS00245), AK acetate kinase (SMUL_1484; SCA02S_RS00240), ME malic enzyme (SMUL_3158; corresponding enzyme in S. cavolei is not present), FH fumarate hydratase (SMUL_1459, SMUL_1679–1680; SCA02S_RS00615-RS00620), FR fumarate reductase (SMUL_0550–0552; SCA02S_RS07735-RS07740)