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. 2018 Nov 19;9:4861. doi: 10.1038/s41467-018-07257-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Effects of Pd CNCs on ascorbate-induced cytotoxicity in vivo. The current clinical medicines, oxaliplatin and 5-fluorouracil (5-FU), are also included for comparison. a Average weight of mice with HCT116 xenografts after different treatments. b Tumor growth curves from HCT116 tumor xenografts in 6–8 week athymic nude mice with ascorbate or Pd CNCs. c Percentage of growth inhibition of mice after the treatment. For all in vivo studies, mice n = 5 per treatment group