Table 2.

Chemoprophylactic strategies and agents

	Chemoprophylaxis strategy
	Suppressive			Causal
Agent	Mefloquine	Doxycycline	Atovaquone–proguanil	Primaquine	Tafenoquine
Dosing	Weekly	Daily	Daily	Daily	Weekly
Post-exposure PART required	Yes	Yes	Yes	No	No
Pregnancy	Yes	No	No	No	No
G6PD-deficient safety	Yes	Yes	Yes	No	No
Children	Yes	No	Yes	Yes	Insufficient evidence
Parasite resistance	Yes	Yes	Yes	No	Improbable
CYP-dependent	No evidence	No evidence	No evidence	Yes	Insufficient evidence