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. 2018 Nov 13;12:271. doi: 10.3389/fnbeh.2018.00271

Figure 1.

Figure 1

Cocaine sensitization disrupts correlation of accumbal neuromedin U receptor 2 (NMUR2) mRNA expression with cocaine-evoked locomotion. (A) The timeline and locomotor activity for cocaine sensitization paradigm. Locomotor activity was measured in animals given saline injection or cocaine injection twice daily for 5 days (n = 14 per group). After 7 days of abstinence, locomotor activity was measured for 1 h following injection on challenge day where control animals received saline and the other groups both received cocaine. (B) Neuropeptide NMU mRNA expression in the nucleus accumbens (NAc; n = 8) and (C) the correlation between NMU mRNA and locomotor activity. (D) NMUR2 mRNA expression in the NAc (n = 8) and (E) the correlation between NMUR2 mRNA and locomotor activity. Data shown as bar graphs are mean ± SEM. *p < 0.05 vs. non-sensitized. Data shown as correlations are individual subjects with correlation line fit to data. p values are reported on correlation figures with *p < 0.05.