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. 2018 Nov 13;12:271. doi: 10.3389/fnbeh.2018.00271

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Copyright © 2018 Kasper, Smith and Hommel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cocaine sensitization disrupts correlation of accumbal NMUR2 protein expression with cocaine-evoked locomotion. (A) Representative immunohistochemistry (IHC) staining for NMUR2 in the NAc with white dashed lines surrounding the NAc and black box indicating the zoomed in area below. Staining patterns for large cell bodies and synaptic puncta can be observed (blue circles). 3V indicates third ventricle, AC indicates anterior commissure, and white bar indicates 10 μm. (B) The quantification of NMUR2 positive staining events (n = 6 per group) and (C) the correlation between the NMUR2 IHC events and locomotor activity. Data shown as bar graphs are mean ± SEM. Data shown as correlations are individual subjects with correlation line fit to data. p values are reported on correlation figures with *p < 0.05.