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. 2018 Nov 13;9:1306. doi: 10.3389/fphar.2018.01306

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Copyright © 2018 Lee, Coelho, Class, Sern, Bocz and Szumlinski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of intra-AcbSh MTEP and adult-onset alcohol consumption upon behavior in the light-dark box. (A) Vehicle-infused adult-onset alcohol-drinking mice made fewer light-side entries than their water controls. Infusion with 1 μg/side MTEP increased the number of light-side entries exhibited by alcohol-drinking mice, compared to vehicle-infused controls. (B) Similarly, vehicle-infused alcohol-drinking mice also spent less time on the light side, compared to water controls, and 1 μg/side MTEP significantly increased light-side time in alcohol-drinking mice, compared to vehicle infusion. (C) There were no significant group differences in the latency to first light-side entry or (D) the distance traveled during the 15-min test. ^∗p < 0.05 treatment effect within same drinking group, ⁺p < 0.05 drinking effect within same intracranial treatment group.