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BET inhibitor drugs and HOTAIR level regulation. BRD4 binding to HOTAIR promoter region causes an upregulation in gene expression for the lncRNA HOTAIR. This overexpression in HOTAIR is associated with proliferation and expansion of GBM tumor cells. BET inhibitors prevent binding of BRD4 to the HOTAIR promoter and yield a down regulation in HOTAIR expression. Subsequently, there is prevention of tumor cell proliferation.
