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. 2018 Nov 13;9:1234. doi: 10.3389/fphar.2018.01234

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Copyright © 2018 Walcher, Budde, Böhm, Reinach, Dhandapani, Ljubojevic, Schweiger, von der Waydbrink, Reimers, Köhrle and Mergler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the effects of CPZ and AMTB on VEGF-induced rises in whole-cell currents in UM 92.1 cells. (A) Time course recording showing the current increases induced by VEGF (10 ng/ml) and after application of 20 μM AMTB. (B) Original traces of VEGF-induced current responses to voltage ramps. Current densities are shown before application (labeled as A), during application of VEGF (labeled as B), and after addition of AMTB (labeled as C). (C–D) Same recordings as shown in (A–B) but with 20 μM CPZ instead of AMTB. CPZ clearly reduced the VEGF-induced whole-cell increases. (E) Summary of patch-clamp experiments with VEGF, AMTB and CPZ. The asterisks (***) indicate statistically significant differences of in- and outward currents with VEGF without and with AMTB (n = 8–40; ***p < 0.005; paired tested). VEGF had no effect in the presence of CPZ.