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. 2018 Nov 13;9:1234. doi: 10.3389/fphar.2018.01234

Figure 4.

Figure 4

CAP does not augment increases in whole-cell currents in VEGF treated UM 92.1 cells. (A) Time course recording showing the current peak induced by 10 ng/ml VEGF and current peak after application of 20 μM CAP. (B) Original traces of VEGF- and CAP-induced current responses to voltage ramps. Current densities are shown before application (labeled as A), during application of VEGF (labeled as B), and after addition of CAP (labeled as C). (C) Summary of patch-clamp experiments with VEGF and CAP. The asterisks (**) indicate statistically significant increase with VEGF (n = 7; p < 0.01; paired tested) and unchanged magnitude of currents in the presence of CAP (n = 4; p > 0.05; paired tested). (D) Maximal negative current amplitudes induced by a voltage step from 0 to −60 mV are depicted in percent of control values before application of 10 ng/ml VEGF. VEGF-induced inward currents (n = 7; *p < 0.05) were not increased in the presence of 20 μM CAP (n = 4; p > 0.05). (E) Maximal positive current amplitudes induced by a voltage step from 0 to +130 mV are depicted in percent of control values before application of 10 ng/ml VEGF. VEGF-induced outwardly rectifying currents (n = 7; *p < 0.05) were not increased in the presence of 10 μM CAP (n = 4; p > 0.05).