Table 5.
Platelet closure time and count, rotational thromboelastometry, and plasma coagulation assay parameters (mean, 95% confidence interval) in dogs (n = 24) with hemorrhagic shock.
| Parameter | Baseline | Shock | P value* |
|---|---|---|---|
| Platelet Closure Time (sec) | 83.4 (77.6–89.1) | 69.0 (65.2–72.8) | <0.001 |
| Estimated Platelet Count (x109 L−1) | 134.3 (124.7–143.9) | 119.4 (106.3–132.5) | 0.057 |
| INTEM CT (sec) | 218.3 (180.9–255.7) | 168.1 (143.2–193.0) | <0.001 |
| INTEM CFT (sec) | 158.5 (135.9–181.1) | 234.6 (203.6–265.6) | <0.001 |
| INTEM α (°) | 61.0 (57.4–64.5) | 58.6 (55.3–61.9) | 0.067 |
| INTEM MCF (mm) | 52.4 (50.5–54.3) | 47.4 (45.4–49.4) | <0.001 |
| INTEM LI60 (%) | 99.3 (98.9–99.8) | 99.1 (98.6–99.7) | 0.458 |
| EXTEM CT (sec) | 54.3 (47.3–61.2) | 66.5 (60.1–73.0) | <0.001 |
| EXTEM CFT (sec) | 148.0 (125.3–170.7) | 193.6 (170.5–216.8) | <0.001 |
| EXTEM α (°) | 63.4 (61.2–65.6) | 62.2 (60.5–63.8) | 0.117 |
| EXTEM MCF (mm) | 52.2 (50.0–54.4) | 45.7 (43.0–48.4) | <0.001 |
| EXTEM LI60 (%) | 96.0 (91.4–100.7) | 84.1 (74.9–93.3) | 0.002 |
| EXTEM TPI | 24.1 (19.8–28.4) | 15.5 (11.8–19.2) | <0.001 |
| FIBTEM MCF (mm) | 5.0 (4.2–5.9) | 3.5 (2.6–4.4) | <0.001 |
| Prothrombin Time (sec) | 7.5 (7.3–7.7) | 8.5 (8.2–8.8) | <0.001 |
| Activated Partial Thromboplastin Time (sec) | 15.4 (14.8–16.0) | 14.4 (13.6–15.1) | <0.001 |
| Fibrinogen Concentration (g L−1) | 1.41 (1.29–1.54) | 0.97 (0.87–1.08) | <0.001 |
| Factor VII Activity (%) | 99.1 (92.5–105.7) | 77.8 (71.7–84.0) | <0.001 |
| Factor VIII Activity (%) | 109.8 (98.0–121.6) | 155.4 (139.9–171.0) | <0.001 |
| von Willebrand Factor Antigen (%) | 100.6 (90.0–111.3) | 74.3 (60.2–88.4) | <0.001 |
*
Paired t-test, bold indicates P < 0.05. α, alpha angle; CFT, clot formation time; CT, clotting time; LI60, lysis index at 60 min; MCF, maximum clot firmness; TPI, thrombodynamic potential index.