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. 2018 Nov 13;9:1599. doi: 10.3389/fphys.2018.01599

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Copyright © 2018 Montoro-Molina, López-Carmona, Quesada, O’Valle, Martín-Morales, Osuna, Vargas and Wangensteen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibrosis related variables. Renal level of fibrosis in Zucker lean rats (A,C) and Zucker obese rats (B,D), Note the significant increase of tubulointerstitial fibrosis in obese rats in comparison with lean rats (A,B Sirius red stain with light microscope, C,D Sirius red stain with polarized light, original magnification 20×). Renal hydroxyproline levels (E) and percentage of renal fibrosis (F). Data are means ± SEM. ^∗p < 0.01 compared with Zucker lean rats (n = 10, each group).